Development of Anti-Alzheimer’s Disease Drugs Based on Aβ Hypothesis

Abstract:

Alzheimer’s disease (AD) is a chronic neurodegenerative disease, which is considered as one of the most intractable medical problems with heavy social and economic burden. Currently, the therapeutic strategies development based on Aβ hypothesis is a research hotspot. The research progress on therapeutic strategies developed based on the mechanism of reducing Aβ synthesis, increasing Aβ degradation, blocking the interaction of Aβ and neurons, and inhibiting Aβ aggregation are reviewed to provide basis for the further development of anti-AD drugs.