Research Advances in Immune Tolerance in Cow's Milk Allergy

Abstract:

Food allergy is an adverse immune response that specific to food allergens, while immune tolerance is defined as the absence of such an immunological reaction to the ingested food antigens. The prevalence of cow's milk is increasing in recent years and most children allergic to cow's milk develop immune tolerance after three years old as reported. Based on these facts, the review introduces milk allergy and the related immune cells that trigger immune tolerance including dendritic cells, regulatory B cells and regulatory T cells, and their roles in immune tolerance. Three methods for inducing immune tolerance are also summarized.