Research Progress on Safety Evaluation of mTGase Cross-Linking for Protein and Related Detection Methods

Abstract:

Microbialtransglutaminase (mTGase), as a high-performance cross-linking enzyme, is often used to improve protein's techno-functional properties, however, more attention should be paid to the potential health problems caused by its protein cross-linking products and its own. Due to the formation of isopeptide bonds, mTGase cross-linking can cause the changes of protein digestibility and immunogenicity. mTGase may act as an autoantigen in patients with celiac disease, causing autoimmune diseases. Therefore, this paper mainly analyzes and discusses the health effects of mTGase cross-linking and the corresponding detection methods, in order to enrich and expand the research field of mTGase and provide reference for the safety application of mTGase.