Research Progress in T Cells and Their Epitopes in Food Allergy

Abstract:

The allergy peptides from food protein digested by gastrointestinal tract were presented by dendritic cell to T cells, which led to allergic reaction. T cells could differentiate into certain subgroups and play different roles in immune reaction. Among them, the down-regulation of Th1/Th2 was considered as a trigger of the hypersensitivity reaction such as food allergy. The role of Th9, Th17, Tfh and other Th cells cannot be ignored in the development of allergic reactions. Therefore, this review comprehensively summarized the research of T cells on food allergy, introducing the roles of T lymphocytes with different subgroup, prediction and mapping of T cell epitopes in common allergen proteins, and the application of T cell epitopes, etc.