Abstract:The study aimed to investigate the uric acid lowering activity of chicken breast hydrolysate enriched with anserine in mice with hyperuricemia. Different sources of hydrolysates enriched with anserine were administrated with different doses to hyperuricemia mice induced by potassium oxonate. The effects of anserine on organ index, serum levels of uric acid (UA), creatinine (CRE) and urea nitrogenand (UN), activities of hepatic xanthine oxidase (XOD) , adenosine deaminase (ADA), aspartate transaminase (AST) and alanine transaminase (ALT), and the content of triglyceride were studied in hyperuricemia mice. Results showed that anserine could effectively alleviate the liver and kidney index. The medium dosage in sample 1 and sample 2 had the most obvious effect, and could effectively reduce the levels of UA, UN and CRE in serum, and the effect was better than allopurinol. Both sample 1 and 2 could inhibit the liver ADA activity in mice, and the effect was not significantly different from allopurinol. However, only the low dosage in sample 1 could significantly reduce XOD activity. Sample 1 could significantly reduce ALT activity, and low dose reduced enzyme activity more than allopurinol, high dose could significantly reduce AST activity. The effect of chicken breast hydrolysate on liver TG content was consistent with the trend of XOD, which confirmed the correlation between TG content and XOD activity. Therefore, chicken breast hydrolysate enriched with anserine can effectively reduce uric acid levels and alleviate hyperuricemia in mice.
