Synthesis of Polyunsaturated Fatty Acid Esters of Resveratrol

Abstract:

To enhance the stability and efficacy of resveratrol and polyunsaturated fatty acids（PUFAs），the esterification products of resveratrol with three kinds of PUFAs，linolenic acid，arachidonic acid and DHA，were synthesized by chemical method. With oxaloyl chloride as acylation reagent，the PUFAs were prepared into corresponding acyl chlorides under the catalysis of N，N-dimethylformamide，and then reacted with resveratrol to form esters. The structures of four resulted resveratrol-PUFA esters were identified by MS，IR，1H-NMR and 13C-NMR. The results showed that resveratrol reacted with linolenic acid to form two monoesters: linolenic acid-3-resveratrol ester and linolenic acid-4'-resveratrol ester. Meanwhile，resveratrol reacted with arachidonic acid and DHA to form triesters: triarachidonic acid-resveratrol ester and triDHA-resveratrol ester，respectively.