Study on Induced Live Injury and Fibrosis By Malus xiaojinensis Polyphenols

Abstract:

The aim of this study was to investigate the anti-hepatic fibrosis mechanism of Malus xiaojinensis polyphenols（MXP）.Mice with Subcutaneous injection of CCl4 were set as the animal model of live injury and fibrosis while those treated with MXP by gavage（10 mg/kg，20 mg/kg） was used as the prevention groups. The results showed that CCl4 caused severe liver injury with increased activity of ALT and AST. Meanwhile the model mice had reduced activity of SOD and GSH-PX. Compared with the model group，MXP decreased the activity of ALT and AST in serum and liver and increased the activity of SOD and GSH-PX significantly. Both morphologic and histological detections indicated that MXP could ameliorate the degree hepatocyte injury and privation of the liver fibrosis. Moreover，feeding of MXP could inhibit the production of IL-1，IL-6 and TNF-α. The study showed that MXP could partly reverse CCl4 induced hepatic fibrosis by enhancing anti-oxidative function and down -regulating inflammatory cytokine synthesis. MXP may be developed as a novel antioxidant for prevention of the liver diseases.