D-Psicose，Favorably Alters Lipid Metabolism in Wistar Rats

Abstract:

This paper was designed to investigate the D-Psicose improved Wistar rat body weight，blood lipid levels，as well as the possible mechanisms of lipid metabolism. The rats were randomly divided into five groups：control group（AIN-76A），glucose group（AIN+Glu），fructose group（AIN+Fru）、D-psicose group（AIN+Psi） and cellulose group（AIN+Cel）. The rats were sacrificed after four weeks and the concentration of total cholesterol（TC），triglyceride（TG），low density lipoprotein cholesterol（LDL-C） and free fatty acid（FFA） in serum were measured. Liver histological analysis was performed by microscopy. The mRNA expression of PPAR-α and FAS in liver were measured by RT-PCR. The result showed that compared with the other diet groups，the body weight，serum TG，FFA，LDL-C level of AIN+Psi group were significantly decreased（P<0.05），but the TC was not significant. RT-PCR result showed that the expression of PPAR-α was up-regulated and FAS were significantly down-regulated in AIN+Psi group（P<0.05），in addition the expression of FAS in AIN+Glu，AIN+Fru and AIN+Cel were higher than AIN-76A. In summary，these results indicate that the D-psicose diet decreases lipogenesis，control blood lipid levels，leading to D-psicose's potential for weight management.