Preparation and Process Optimization of Curcumin-Cyclodextrin Inclusion Complexes

Abstract:

In order to improve the water solubility of curcumin（CCN），curcumin-cyclodextrin inclusion complexes（CCIC） were prepared and the preparing process was optimized. The CCIC was prepared by grinding method. Microscopic observation method，differential scanning calorimetry，and infrared spectroscopy method were used to validate the formation of the CCIC. The orthogonal design was used to optimize the preparation process of CCN. Solubility was a evaluation index. The optimal condition of these three effects to prepare CCN were that the inclusion of feed ratio was 1∶1，the grinding temperature was 40 ℃，the inclusion time was 1.5 h. The solubility of CCN in inclusion complex prepared by optional condition was（1.72±0.03） mg/mL which increased 3.82×104 times compared with free drug. The process was stable and feasible. The preparation process was repeatable and reasonable. It effectively improved the solubility of CCN in the water.