Application of Fussy Evaluation Combined with Response Surface Test in the Formulation Optimization of Glucosamine Chondroitin and Calcium Chewable Tablets

Abstract:

Preparation of bone density-enhancing health food glucosamine chondroitin and calcium chewable tablets was studied. With flavor、taste and appearance as three indicators，response surface experiment was designed on the basis of single factor experiment，which combined with fussy comprehensive evaluation to determine the best formula. The optimized process parameters for chewable tablets was as follows：the content ratio of rawmaterial，mannitol，xylitol，lactose and milk powder was 100∶30∶10∶8∶16. Under this condition，the chewable tablets showed a smooth surface with uniform color，tasted delicate and sweet with unique milk flavor.