Optimization of Self-Microemulsifying Drug Delivery System for Naringenin-β-Cyclodextrin Inclusion Complex by Central Composite Design and Response Surface Method

Abstract:

This study was aim to investigate the formula of self-microemulsifying drug delivery system for naringenin naringenin-β-cyclodextrin（NAR-β-CD） inclusion complex by central composite design-response surface method. The solubility test of NAR-β-CD inclusion complex in different secondary solvents and pseudotemary phase diagam were utilized to select components of NAR-β-CD inclusion complex self-microemulsifying drug delivery system. According to the drug loading and particle size of naringenin in different self-microemulsifying drug prescriptions，the optimal prescription was determined using the central composite design and response surface method. The optimal prescription of NAR-β-CD inclusion complex self-microemulsifying drug delivery system was composed of Ethyloleate（oil），Polysorbate 80（surfactant），and PEG 400（co-surfactant），with oil ratio of 14.39%，and the Km at 2.05. The drug loading of naringenin was 159.435 mg/g，and particle size was 28.35 nm.