Effect of Different Edible Fungi on the Bioactivity of Anti-Insulin Resistance in Insulin Resistant Cells

Abstract:

The effect of nine different edible fungi ethanolic extracts （Phellinus baumii，Ganoderma lucidum，Cordyceps militaris，Agaricus blazei，Coprinus comatus，Lentinula edodes，Grifola frondosa，Hericium erinaceus and Pleurotus eryngii） on glucose consumption was investigated in two models of insulin-resistant cells （high concentration insulin-induced HepG2 and dexamethasone-induced 3T3-L1）. The glucose consumption of alcoholic extracts from the edible mushroom using four different organic solution （petroleum ether，chloroform，ethyl acetate and n-butanol phase） from G. Lucidum or P. Baumii was detected in the two cell models. The cell glucose consumption was greatly enhanced by the ethanolic extracts from G. Lucidum or P. baumii in HepG2 model. A better result of glucose consumption was achieved for the two groups with high-concentration compared with the positive control. The cell glucose consumption was also effectively promoted by P. baummi extracted by petroleum ether，ethyl acetate or n-butanol，and similar improvement was observed in G. Lucidum extracted with four types of organic solvents. The glucose consumption increased by ethanolic extracts from G. Lucidum and P. baumii in the study of 3T3-L1 adipocyte cell model. The extracts from P. baummi and G. Lucidum by ethyl acetate facilitated the glucose consumption.