Preliminary Study on the Stability of Chitosan-Modified Liposomes Containing L-Asparaginase

Abstract:

To investigate the in vitro stability of chitosan-modified liposomes containing L-asparaginase （LACL），the optimal pH，temperature，storage stability，pH stability，thermal stability and proteolytic stability were investigated in this study. The optimal pH values of L-ASP and LACL were at 7.5 and 7.0，respectively. The optimal temperatures of L-ASP and LACL were at 60 ℃ and 50 ℃，respectively. The stabilities of LACL were higher than that of L-ASP. The results shown that the stability of L-ASP was significantly enhanced by the LACL.