Comparative Study of Pharmacokinetics Between Monomer Bisdemethoxycurcumin and Curcumin

Abstract:

To evaluate the pharmacokinetics of bisdemethoxycurcumin（CurIII） and curcumin （CurI） in SD rats by oral administration. Twelve male rats were random divided into two groups and were orally administrated of CurIII and CurI suspension，the blood samples were collected and of CurIII and monomer CurI concentration in blood was determined by HPLC. The data were processed by DAS 2.1.1 software to calculate the pharmacokinetic parameters. The pharmacokinetic parameter of CurIII and monomer CurI were calculated as follows：Tmax 0.75 and 0.25 h，Cmax（62.90±2.64） μg/L and （61.64±4.30） μg/L，AUC0~72 h（281.75±3.61） μg/（h·L） and （171.79±32.18） μg/（h·L），AUC0~∞（291.31±15.15） μg/（h·L） and （190.46±43.81） μg/（h·L），respectively. Compared with monomer CurI，CurIII has better bioavailability.