Prothetic Effect of Flat-European Hybrid Hazelnut Oil on Partial Organs of Rats with Hyperlipidemia

Abstract:

The hyperlipidemia model of SD rats was established and handled with gavage. The physiological indexes and histopathologic of kidneys，hearts and skeletal muscles in the model rats were observed to determine the effect of the Flat-European hybrid hazelnut oil on partial organs of rats induced by high fat diet. The results of kidney indexes test showed that the superoxide dismutase (SOD) activity was significantly increased by 2%，6%，and 15%，respectively for the high fat group treated in low，middle，and high doses using Flat-European hybrid hazelnut oil，while a significant decrease of malonaldehyde (MDA) content by 14%，28%，and 32%，and a significant increase of catalase (CAT) activity by 22%，39%，and 57%，comparing with the high fat control group. Another decrease of triglyceride (TG) content by 13%，13%，37%，and 34% was observed for soybean oil and hybrid hazelnut in low doses group，and hazelnut oil in middle and high dose group compared to the high fat control group. The results of heart indexes test showed that the differences of SOD activity and MDA content were not significant for the groups treated in low and middle doses with Flat-European hybrid hazelnut oil，however，an increase of SOD activity by12% and a decrease of MDA by 30% were significantly observed for the groups treated in high doses of Flat-European hybrid hazelnut oil. The TG contents of the groups treated with soybean oil and hybrid hazelnut in low doses significantly decreased by 8% and 7%，while those of the groups treated with hybrid hazelnut in middle and high doses extremely significantly decreased by 33% and 33%. The alanine aminotransferase (GPT) content increased by 31%，34%，33%，and 21% for soybean oil and hybrid hazelnut in low doses group，hazelnut oil in middle and high dose group compared to the high fat control group. The results of skeletal muscle test presented significant changes in SOD activity，glutathione peroxidase (GSH-Px) activity，MDA content and TG content for the high fat groups treated with Flat-European hybrid hazelnut oil. However，the change in cholesterol (TC) content was not obvious. This study revealed that the antioxidant ability of the high fat group could be improved by dosing Flat-European hybrid hazelnut oil，and the prothetic effect for kidneys，heart，and skeletal muscle was observed.