Protective Effect of Selenium-Enriched Barley Seedling on Ethanol-Induced Gastric Ulcer in Mice

Abstract:

The present work aimed to investigate the influence of selenium-enriched barley seedling on ethanol-induced gastric ulcer by establishing a mice model of ethanol-induced gastric ulceration. The model mice were orally administered SEBS at different doses （0.1，0.5，1 g/mL）. The ratio of ulcer area to total stomach area （ulcer area ratio，UAR） was quantified by different methods including image integration method，gravimetric method，score method and grading method. The results were analyzed using statistic analysis. The ethanol-induced gastric ulcer in mice could be effectively prevented by SEBS （P<0.05） comparing the results of the model groups and the control groups. The protective effect was proportional to the concentration of SEBS. The results suggested that selenium-enriched barley seedling had significant ameliorative effect on ethanol-induced gastric ulcer in mice.