SDS+HCl Catalyzed Synthesis of Hydrophilic Phytosterol Esters

Abstract:

The present study was to synthesize novel hydrophilic phytosterol esters through an intermediate phytosterol hemisuccinate, which was first prepared with phytosterols and succinic anhydride and subsequently coupled with polyethylene glycol. The effects of micelle catalyst and reaction conditions were investigated. Results showed that the combination of sodium lauryl sulfate and hydrochloric acid was highly efficient in the catalysis for the ester synthesis. The optimum reaction conditions were: 6% catalyst dose (w/w), 1∶2 molar ratio of phytosterol hemisuccinate to phytosterol polyethylene glycol succinate at 140 ℃ for 2 h. With the optimum conditions, the conversion reached above 96%.