Review on Metabotype

Abstract:

Metabotype concept has been widely used in pharmacometabonomics and nutrigenomics，which also provides a new bioanalytical territory for personalized treatment. Different from the metabolic phenotype，metabotype has a clear definition. Metabotype is mainly determined by the genome，the intestinal flora，environment and the intakes，which can be described by four criteria，i.e.，metabolites，their concentrations，their ratios and the metabolic profiles. The model established via the four criteria，which is useful in the biological field，was applied to study Aflatoxins B1 in this paper，providing a new perspective for its application.