Study on Chronic Toxicity Test of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng on Rats

Abstract:

To observe the long-term toxicity and its severity of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng by rat experiment and provide safe dosage for its clinical usage. The rats were randomly divided into four groups: high(2.0 g/kg), middle(1.0 g/kg), low(0.5 g/kg) group and blank group. The drug group was given oral of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng for 180 consecutive days and observe the changes of the rats' common condition、body weight、hematology、blood biochemistry 、liver and kidney function、coefficient of important organs 、histological during medication and the recovery condition within 30 days of stopping medication. Results shows the long-time use of Tibetan Radix Rhodiolae Changbaishan Wild Ginseng may have a certain impact on some indicators of live function、kidney function、creatine kinase、blood lipids and blood. This experiment indicates that the safe dose of its long-term use should not more than 0.5 g/kg daily.