Microwave Assisted Synthesis of Mannosyl Trichloroacetimidate and Its Process Improvement on Traditional Synthetic Method

Abstract:

Mannose-oligosaccharides and mannose glycoprotein play an important role in many physiological processes, their synthesis is a vital branch of carbohydrate chemistry. Mannosyl trichloroacetimidate is a very efficient glycosyl donor in their synthesis. This paper investigated the new microwave assisted synthesis of mannosyl trichloroacetimidate, and optimized the traditional synthetic method. It was synthesized from D-mannose by benzoyl protection, hydrolysis and then reaction with trichloroacetonitril. Its existing methods were optimized and total yield was more than 85%. Meanwhile it was synthesized by the microwave assisted method firstly. The experiment result indicated the total yield in new method was more than 12% compared with that in traditional method, while the reaction time was shortened about 15 times.