Three-Dimensional Structure Prediction of Influenza A (H1N1) Virus

Abstract:

Basing on the HP model of protein spatial structure, this paper searches the protein three-dimensional structure of the influenza A(H1N1) virus according to the method of ab initio. This paper establishes the 3DHP model of the Influenza A(H1N1) virus protein spatial structure and uses the improved genetic algorithm to find the structure with minimum free energy, aiming at predicting the influenza A(H1N1) virus protein three-dimensional structure. Before correlation analysis and significance test, protein spatial structure data establishes distance matrices. The significance is to illustrate the highly consistent relationship between prediction structure and known structure. The model provides a quick method to predict the spatial structure of the influenza a (H1N1) virus.