Influence of Side Chains of β-cyclodextrin Derivatives on Cavity Hydrophobicity

Abstract:

Cyclodextrin cavity polarity is one of the driving forces of incorporating molecules selectively to form inclusion complexes, however, very few studies have reported. This paper aims at studying the cavity polarity of β-cyclodextrin and its three different derivatives(hydroxypropyl-β- cyclodextrin, methyl-β-cyclodextrin, sulfobutyl ether-β-cyclodextrin) by using pyrene as a fluorescent probe. The results show that the pecking order of hydrophobicity of four kinds of cyclodextrin cavity is M-β-CD