Advances in Metabolic Engineering of Branched-Chain Amino Acids Producer

Abstract:

The branched-chain amino acids(leucine,isoleucine and valine) are synthesized by bacteria,fungi and plants. They are essential for vertebrates including humans who must receive branched-chain amino acids from their diet. They play an important role in metabolic life because of the special structure and function. Therefore,branched-chain amino acids are used in medicine, food industry and feed ingredient. Fermentation is the main method to produce branched-chain amino acids. Corynebacterium glutamicum(including Brevibacterium flavum) is the main producer. Biosynthesis and regulations of branched-chain amino acids are analysed and the developments in metabolic engineering-breeding are summarized.