Effect of Egg Yolk Powder Hydrolysis Bonepep on the Bone Metabolism

Abstract:

In this manuscript,the effect of the egg yolk powder hydrolysis(Bonepep) on bone metabolism was investigated at rat and human level. When 10 mg/(kg·d) and 100 mg/(kg·d)Bonepep was fed to SD mice led the mice tibia elongation increased by 4.5% and 10.3%,respectively. And the physiological and biochemical indexes of mice were constant when mice were explored to high doses of Bonepep for long time. It was found that Dpyr level in urine was decreased 84.6%,and the thigh bone was significantly reduced when mice was fed Bonepep. For the female volunteers,the level of DPD and NTx,reflect the characters of bone resorption,were not significantly changed,after 5 weeks continuous taking Bonepep. However,the BALP activity,a index for bone formation,was increased by 14.6%. These results demonstrated that the egg yolk powder hydrolysis Bonepep could effectively inhibit osteoclast differentiation but promote bone growth.