Advances in Production and Application of α-Keto Acids

Abstract:

α-keto acids,a kind of bifunctional substances combined with biological activities,are widely used in feed,food additives,chemical synthesis,etc. Currently α-keto acids are produced by chemical synthesis,with the disadvantages of mutiple reaction steps,serious environmental pollution,and low product yield. Compared with the chemical synthesis,biotechnological production of α-keto acids is an abstractive approach due to the low cost,mild conversion conditions as well as environment-friendly mode of production,which have attracted increasingly attention of researchers.In this work,we reviewed the progress of chemical synthesis method,fermentation method,and biotransformation to produce α-keto acids. Finally,the development prospects in this field were outlined.