Character Changes of Taste Buds in Mice Circumvallate Papillae of Streptozotocin-Induced Diabetes

Abstract:

Diabetes mellitus(DM) are induced in ICR mice with the dose of 180 mg/kg of streptozotocin(STZ) and then the morphological changes and the expression related with taste signal transduction of taste buds in vallate papillae are evaluated by hematoxylin-eosin staining and immune-histochemical methods.The results show that the number and the size of taste buds have no significant difference between control and DM mice.Whereas,compared with control mice,the DM mice have more number of α-gustducin and phospholipase Cβ2 positive cells per taste bud(P< 0.05/P<0.01).By contrast,the DM mouse have less number of SNAP-25 cells per taste bud than that of control mice(P <0.01).In a word,taste changes caused by DM maybe result from the expressed change of the taste signal transduction proteins,which block the peripheral taste signal to transmit to to the gustatory afferent nerve.