Evaluation of the Antimicrobial Properties of Grape Seed Extract and Its Polyphenol Components Against Oral Pathogenic Bacteria

Abstract:

To study the antibacterial activity of grape seed extract(GSE) constituents(most of them are polyphenolic compounds) against periodontitis and cariogenic bacterial,the relationship between the structures and the antibacterial activities was investigated with optical density(OD) test and the minimum inhibition concentration(MIC) as index.As the result,the fraction with high polarity which is very dissoluble in water has stronger inhibition ability than other fractions with lower polarity.Among the water dissoluble fraction,those compounds with three consecutive hydroxyl groups seems to be very important to antibacterial activity.That is to say,the inhibition factors in the GSE are those phenolic compounds with three consecutive hydroxyl groups but not the procyanidins as what we expect.