Stability of IL2-HSA Solution

Abstract:

The stability of interleukin2-HSA fusion protein was examined in different pH and buffer solution environments using SDS-PAGE and SE-HPLC.A pH-5 solution of Acetic acid Sodium acetate buffer is found to be more suitable for IL2-HSA to preserve stability.Several excipients was tested for the effect to protein stability under elevated storage temperature and photostability test was taken,the protein was proven to be stable throughout photo-stability test,after a 6month-long storage NaCl is considered to be a better excipient for IL2-HSA than its rivals.