Research Progress on NADPH Metabolism in Constructive Metabolism of L-lysine

Abstract:

As one of the essential amino acids for human beings and animals and one of the first restrictive amino acids for human and plants,L-lysine has many functions,such as balancing amino acid composition,adjusting in the body metabolic balance,accelerating the rate of absorption of protein,promoting the growth and development of animals,improving the utilization of protein.It takes around 4 mol NADPH to produce 1 mol L-lysine.However,it takes around 1 mol NADPH to produce 1 mol L-glutamic acid.Therefore,the improvement of NADPH in the pathway of L-lysine fermentation is one of the key factors to increase the output of L-lysine.This paper stated the research evolution focus on aspects of the L-lysine biosynthetic pathways of Corynebacterium glutamicum,the metabolism of NADPH and the NADPH-metabolizing enzymes.