Abstract:The objective of this study is to investigate the effects of OCT on blood glucose,lipid and anti-oxidation function of mice fed with high-fat diet.For this,Process and Methods: Three weeks feeding of C57BL/6 mice was divided into normal group(control),high-fat group(HFD),high-fat +octreotide(OCT) group,high-fat +0.1 wt % lipoic acid(LA) group,and feed 3 weeks.Among them,the OCT group were injected 0.1mL of OCT(20?g/ k g) during the third week,oral glucose tolerance test(OGTT) was done at the end of the third week.The levels of blood TC,TG,HDL-C,LDL-C,AI,levels ROS,CAT,T-AOC,MDA of liver,muscle,fat and brain were measured.It was found that OCT significantly reduce the curve size of blood glucose in OGTT experiment.Compared with HFD group(p<0.05),OCT decreased the levels of TC,TG,LDL-C,AI but increase HDL-Clevel.OCT injection could significantly reduce the levels of ROS,MDA and increase the levels of CAT,T-AOC in tissues of liver,muscle,fat and brain compared with HFD group(p<0.05,which indicated that OCT injection can improve lipid metabolism and alleviate oxidative stress in mice fed with high-fat diet.
