Abstract:The toxicity,the analgesic and anti-inflammatory effect of Semen strychni integrative fermentation with six different fungi,including Schizphylhls commne Fr.,Shiraia bambusocola P.Henn,Coriolus unicolor (L.:Fr.) Pat.,Cantharellus Cibarius Fr.,Beauveria bassiana (Bals.) Vuill and Cordyceps gunnii (Berk.) Berk were evaluated in this manuscript.When Semen strychni raw materials (RMSS) were solid-fermented with those fungi,the corresponding product were named as SCSS,SBSS,CUSS,CCSS,BBSS and CGSS,respectively.LD50 (i.g.) in mice were determined by the Bliss method to evaluate the acute toxicity of RMSS,processed Semen strychni (PSS) by traditional Chinese method and the six fermented products.The body writhing induced by i.p.0.1% acetic acid and the ear edema induced by 2% croton oil were used to test the analgesic and anti-inflammatory effects of six fermented Semen strychni products with the positive controls of diclofenac sodium (DSE) and RMSS.The toxicities of SCSS,SBSS,CUSS,CCSS,BBSS and CGSS were lower than that of RMSS,and were similar to that of PSS.The analgesic and anti-inflammatory effects of the aboved six fermented products were similar to that of RMSS.In conclusion the six different fermented Semen strychni had the same advantageous effects as that of PSS and the acute toxicity of them could be decreased compare to that of RMSS.
