Update of Techniques for Screening of PDE-5 Inhibitors as Illegal Adulterant

Abstract:

The success of licensed phosphodiesterase type-5 (PDE-5) inhibitor drugs (viz sildenafil,vardenafil and tadalafil) has led to the widespread use as adulterants in herbal dietary supplements or herbal medicines.Which cause a threat to the public health,in this review,the apply progress of TLC,HPLC,LC-MS and MECC in the analysis of known PDE-5 drugs with the standards were summarized.However,only LC-ESI-MS/MS can be competent for the identification of both the licensed PDE-5 drugs and unknown analogues in herbal products simultaneously.It is believed that Immunoassay may be a promising strategy for rapid detecting of undecared PDE-5 drugs in a simple,sensitive and high-throughput way.