Determination of Total Aristolochic Acids and Aristolochic Acid Ⅰ in Radix aristolochiae after Fermentation

Abstract:

With Radix aristolochiae as substrate,twenty fungi was test and 13 different fungi were found to be grown on it.Compare with that of the control,the AA Ⅰ content was decreased in those 13 fermentation product,and the AA Ⅰ content in 6 fermentation product was lower than 50%,compared with that of the control.Similarly,the TAA contents were also detected to be decrease.Among of them,the highest and lowest rate of decline was 46.76% and 7.61%,respectively.After statistical analysis,the ability to decompose the nephrotoxic substances in Radix aristolochiae of the 13 fungi was illustrated as follows(from the strong to the weak): F-1> F-2> F-5> F-6> F-8> F-13> F-4> F-11> F-3> F-9> F-10> F-12> F-7(the symbol of different fungi).Those results indicated that different fungi fermentation could efficient decrease the nephrotoxic components in Radix aristolochiae.