Reconstruction Gene Regulatory Network Depend on by Energy Factor

Abstract:

Reconstruction of gene regulatory network can help to explore the essence of life.The Linear Combination Model has been successfully applied to the reconstruction of the gene regulator network,since it is very simple and can be easily solved.However,the linear relationships between genes were only considered in the model.In order to circumvent this problem,energy factor has been added in the Linear Combination Model,thus the new model can be used to analysis the nonlinear relationships between genes.Then the present model has been applied to reconstruct the gene regulatory network of Escherichia coli on SOS DNA repair process.Our result demonstrated that the proposed model can be reconstruct SOS DNA repair process well and also improve the accuracy.