Effect of Melatonin on Inflammaofory and Anti-Inflammatory Balance of Mice

Abstract:

In this study,the physiological parameters of melatonin live,including inflammatory cytokine IL-1,IL-10 of spleen,intestinal myeloperoxidase(MPO) were determined after LPS treat.It was found that content of IL-1 and MPO activity decreased but IL-10 increased after 4 h stimulation by LPS.For the case of 16 h,the values of IL-1,IL-10 and MPO activity were lower than that of 4 h.The results indicated melatonin can depress inflammation induced by LPS,maintain inflammatory and anti-inflammatory balance and protect animals from injury.