含铁牛血肽改善大鼠缺铁性贫血的效果评价

Effect Evaluation of Iron-Containing Bovine Blood Peptide on Iron-Deficiency Anemia Improvemnet in Rats

摘要:

为开发牛血肽相关功能性产品提供理论依据，作者研究了含铁牛血肽对于大鼠缺铁性贫血的治疗效果。以低铁鼠粮饲喂初离乳雌性SD大鼠3周，建立缺铁性贫血模型。以含铁鼠粮为正常对照，以生血宁为阳性对照，用含铁牛血肽灌胃至血红蛋白质质量浓度达到100 g/L以上。结果表明：含铁牛血肽显著地改善了缺铁性贫血引起的大鼠体质量以及白细胞、红细胞、血红蛋白和红细胞压积等血常规指标的下降，同时改善铁代谢指标血清铁和血清铁蛋白。低剂量牛血肽效果相当于生血宁，中高剂量牛血肽效果优于生血宁，证明饲喂含铁牛血肽可以改善大鼠缺铁性贫血。

Abstract:

This study aimed to explore the therapeutic effect of iron-containing bovine blood peptide on iron-deficiency anemia (IDA) in rats, and to provide a theoretical basis for the development of functional products from bovine blood peptides. Early weaned female SD rats were fed with low-iron rat diet for 3 weeks to establish an iron-deficiency anemia model. Iron-containing rat diet was used as the normal control, and Shengxuening was used as the positive control. Rats were orally administered with the iron-containing bovine blood peptide until the level of haemoglobin exceeded 100 g/L. Changes in rat body weight and blood routine were monitored during the experiment. Iron-containing bovine blood peptide significantly improved the body weight and increased the hematological parameters such as leukocytes, red blood cells, hemoglobin, and hematocrit caused by iron-deficiency anemia in rats. At the meanwhile, it improved iron metabolism indicators, including serum iron and serum ferritin. The effects of low-dose bovine blood peptide were comparable to Shengxuening, while the medium-does and high-dose bovine blood peptide showed better effect than Shengxuening. Oral administration of iron-containing bovine blood peptide could effectively improve iron-deficiency anemia in rats.