纳米Ag@TiO2、Fe@TiO2和Zn@TiO2的抑菌活性比较研究

Comparative Research on Antibacterial Activity of Nano-Ag@TiO2, Fe@TiO2 and Zn@TiO2

摘要:

探索常见金属离子掺杂对抑菌片的抑菌性能的影响，为新型纳米TiO₂抑菌片的制备与改善提供依据。选择固定质量分数的Ag⁺、Zn²⁺和Fe³⁺掺杂TiO₂，通过抑菌圈、最小抑菌质量浓度（MIC）与最小杀菌质量浓度（MBC）综合评价其抑菌性能，对微观结构进行表征分析，探讨抑菌性能差异的原因。结果表明：抑菌性能大小顺序为Ag@TiO_{2> Zn@TiO2> Fe@TiO2， Zn@TiO2的抑菌活性较好但抑菌稳定性差。Ag@TiO2对大肠杆菌和金黄色葡萄球菌的MIC、MBC均是10、20 mg/L，Zn@TiO2对大肠杆菌和金黄色葡萄球菌的MIC、MBC均是30、50 mg/L。表征发现抑菌活性强弱主要归因于纳米TiO2表面与金属离子共同产生的活性位点数量及稳定性，与孔结构或表面官能团的关联不大。}

Abstract:

This study aimed to investigate the antibacterial properties effect of common metal ions doping on antibacterial tablets, providing a technical basis for the preparation and improvement of novel nano-TiO₂ antibacterial tablets. The fixed mass fractions of Ag⁺、Zn²⁺and Fe³⁺ doped on TiO₂ antibacterial tablets were selected for comparative research, and the antibacterial properties were in-depth evaluated by antibacterial circle, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) methods. The microscopic structure was characterized and analyzed to investigate the reasons for the differences in antibacterial properties. The results showed that the order of antibacterial activity was Ag@TiO₂>Zn@TiO₂>Fe@TiO₂. Zn@TiO₂ had higher antibacterial activity but poorer antibacterial stability. The MIC and MBC of Ag@TiO₂ for Escherichia coli and Staphylococcus aureus were 10 mg/L and 20 mg/L, while those of Zn@TiO₂ were 30 mg/L and 50 mg/L, respectively. Characterization revealed that the antibacterial activity was mainly attributed to the number and stability of active sites produced by the interaction between the nano-TiO₂ surface and metal ions, and it was not closely related to the pore structure or surface functional groups.