miRNA影响苯并[a]芘诱发毒性的机制研究进展

Advances in Mechanism Study of miRNA on Toxicity Induced by Benzo[a]pyrene

摘要:

苯并[a]芘（B[a]P）作为多环芳烃类化合物（PAHs）中毒性最大的一种强致癌物，广泛存在于高温加工食品中。大量流行病学研究表明，B[a]P与许多疾病的发生发展密切相关。微小RNA（miRNA）是短的（17–25个核苷酸）非编码RNA，通过mRNA降解或翻译抑制负调控特定的靶基因。miRNA在B[a]P诱发致癌性、生殖毒性、神经毒性等过程中发挥重要作用。本文根据现有的研究发现，对miRNA在B[a]P毒性过程中的作用机制作一综述，旨在深入揭示B[a]P的毒理机制并为其疾病预防和食品安全控制提供新的研究方向和思路。

Abstract:

Benzo[a]pyrene (B[a]P), as a polycyclic aromatic hydrocarbon (PAHs) with the highest toxicity and a potent carcinogen, widely exists in the high-temperature processed food. A large number of epidemiological studies have shown that B[a]P is closely related to the occurrence and development of many diseases. MicroRNA (miRNA) is a short (17-25 nucleotides) non-coding RNA, which negatively regulates specific target genes through mRNA degradation or translation inhibition. MiRNA plays an important role in the process of B[a]P-induced carcinogenicity, reproductive toxicity, neurotoxicity, and other processes. Based on the existing findings, this study reviews the mechanism of miRNA in the toxicity process induced by B[a]P, aiming to further reveal the toxicological mechanism of B[a]P and to provide new research directions and ideas for the disease prevention and food safety control.