Abstract:Nanostructured lipid carriers (NLCs) are an effective means to improve the oral bioavailability of curcumin (Cur), but the stability and application fields of Cur-NLCs prepared under conventional conditions need to be studied and explored. The gel microspheres with multiple responsiveness were constructed by the composite of Cur-NLCs and magnetic gelatin using electrospray. The particle size, appearance, micromorphology, storage stability, multiple responsiveness and release characteristics of the microspheres containing different mass fractions of magnetic gelatin were studied. The results showed that the prepared microspheres were rough ellipsoid, and the particle size decreased from （231.67±2.82） μm to （175.22±1.96） μm with the increase of magnetic gelatin mass fraction. Meanwhile, the microspheres had good stability during storage, and the retention rate of Cur was generally above 80% after 28 d storage at 4 ℃. Multiple response experiments showed that the microspheres were sensitive to magnetic, temperature, acidic pH and NaCl. The in vitro release test showed that the microsphere had an S-shaped Cur release curve, and the pH and NaCl of the release medium affected the release behavior of Cur. The research showed that the constructed microsphere could be an intelligent delivery system with multiple responsiveness and good stability, showing the practical significance for the expanded application of Cur-NLCs in the food industry and the development of intelligent delivery system.
