水生动物原肌球蛋白致敏原研究进展

Research Progress on Tropomyosin Allergen in Aquatic Animals

摘要:

原肌球蛋白（tropomyosin，TM）是甲壳类动物中的一种常见的泛致敏原，同时部分鱼中TM致敏性已得到证实。其蛋白质结构保守、同源性高、致敏性强，且具有广泛的免疫交叉反应。原肌球蛋白致敏性及其消减方法、免疫交叉反应都与抗原表位有关。因此，表位研究是原肌球蛋白研究中的重点。本文中介绍了国内外水生动物原肌球蛋白的性质、表位、免疫交叉反应、致敏性及其消减的研究进展。

Abstract:

Tropomyosin(TM) is a common pan-allergen in crustaceans, and its allergenicity is also confirmed in certain kinds of fish. Tropomyosin has a conservative structure, high homology, strong allergenicity and extensive immune cross-reactivity. The studies of tropomyosin allergenicity and its reduction method, immune cross-reaction are all related to the epitope on tropomyosin. Accordingly, epitope is the key target of tropomyosin research. This article briefly reviews the recent progress in aquatic tropomyosin study, including the properties, epitopes, immune cross-reactivity, allergenicity and its reduction.