金钗石斛水提物对高血脂症大鼠的降血脂作用

Effect of Dendrobium Nobile Aqueous Extract on Decreasing Blood Lipid in Rats with Hyperlipidemia

摘要:

研究金钗石斛水提物对治疗性高血脂症大鼠的降血脂作用及其机制。水提法制备金钗石斛水提物；取成年雄性Wistar大鼠32只，随机分为空白对照组、模型组、金钗石斛水提物低、高剂量组（分别相当于生药量0.425、2.55 g/（kg·d）），空白组饲喂普通饲料，其他组均给予高脂饲料。8周后测定大鼠血清中TG、TC、LDL-C、HDL-C、AST、ALT，肝脏中MDA、SOD、CAT、GSH-Px、LPL、HL和PHPA，粪便中TC、TG和总胆汁酸浓度。与模型组比较金钗石斛水提物低、高剂量组，均显著降低血清中TG、LDL-C的浓度，降低ALT活性，升高HDL-C浓度，肝脏中MDA降低，而SOD、CAT、GSH-Px、LPL和HL活性升高，粪便中TG和总胆汁酸浓度升高。金钗石斛水提物能够显著降低血脂，对高血脂症大鼠有治疗作用。

Abstract:

To investigate the hypolipidemic effect of Dendrobium nobile Aqueous Extract（DNAE）in hyperlipidemic rats and its mechanisms. Thirty-two Wistar rats were randomly divided into normal control group，hyperlipidemia model group，low and high dose groups（0.425，2.55 g/（kg·d））.The normal control group was fed with normal diet and others three groups were fed with high-fat diet. After administrations for 8 weeks，the contents of serum TG，TC，LDL-C，HDL-C，AST and ALT were measured. The contents of liver MDA，SOD，CAT，GSH-Px，LPL，HL，PHPA and TC，TG，total bile acid in feces were detected. Compared with the model group，DNAE could decrease the contents of serum TG，LDL-C，ALT and liver MDA ，increase the contents of serum HDL-C，increase the activity of liver SOD，GSH-Px，CAT，LPL and HL，increase the contents of feces TG and total bile acid. CONCLUSION：DNAE can obviously decrease blood lipid and therefore it can be applied for treatment of hyperlipidemic rats.