药用植物对肿瘤细胞分化诱导作用研究进展

Advances on Medicinal Plants in Inducing Differentiation of Cancer Cells

摘要:

肿瘤的诱导分化研究一直是肿瘤治疗研究领域行之有效的手段之一。自采用全反式维甲酸进行诱导分化，对急性早幼粒细胞白血病治疗取得了较好的疗效后，诱导分化就吸引了越来越多学者的注意。药用类植物不仅具有药用价值，还具有一定的食用价值和经济价值。目前越来越重视药用类植物的开发利用，药用植物来源的分化诱导剂因其副作用小、毒性低等优点被较广泛地应用于治疗肿瘤细胞研究中。本文综述了药用植物源活性成分在肿瘤细胞诱导分化治疗研究领域的现状及其相关作用机制。

Abstract:

Induction of cancer cell differentiation has been one of the means of effective cancer treatment research. All-trans retinoic acid induced differentiation of acute promyelocytic leukemia treatment achieved good results，so the induction of differentiation to attract more and more scholars' attention. Medicinal plants not only has medicinal value，but also have some food value and economic value. At present，attach importance to the development of the use of medicinal plants and more and more of the differentiation-inducing medicinal plant which because side effects，low toxicity are more widely used in the treatment of tumor cells in the study. This paper reviews the status of medicinal plants' active ingredient in tumor cell differentiation therapy research in the field and its related mechanism of action.