平欧榛子油对高血脂大鼠部分器官的修复效应

Prothetic Effect of Flat-European Hybrid Hazelnut Oil on Partial Organs of Rats with Hyperlipidemia

摘要:

建立SD大鼠高血脂症模型并作灌胃处理，通过测定模型肾脏、心脏、骨骼肌生理指标及其组织病理变化，确定平欧榛子油对高脂血症大鼠肾脏、心脏、骨骼肌的修复效应。肾脏指标测定结果显示，饲喂平欧榛子油低剂量、中剂量、高剂量高血脂大鼠超氧化物歧化酶（SOD）活性较高脂对照组差异显著，分别提高了2%、 6%、15%；丙二醛（MDA）含量与高脂对照组差异也显著，分别降低了14%、28%、32%；过氧化氢酶（CAT）活性与高脂对照组差异极显著，分别提高了22%、39%、57%；豆油组、低剂量组、中剂量组、高剂量组甘油三酯（TG）水平较高脂对照组分别降低了13%、13%、37%、34%。心脏指标测定结果显示，饲喂平欧榛子油低剂量组、中剂量组的高血脂大鼠SOD活性、MDA含量差异不显著，高剂量组SOD活性、MDA含量差异显著，SOD提高了12%，MDA降低了30%；豆油和低剂量组TG水平显著降低，分别降低了8%、7%，而中剂量组和高剂量组TG水平极显著降低33%、33%；豆油组、低剂量组、中剂量组、高剂量组谷丙转氨酶（GPT）含量较高血脂对照差异显著，分别提高了31%、34%、33%、21%。骨骼肌指标测定结果显示，饲喂榛子油的高血脂大鼠SOD和谷胱甘肽过氧化物酶（GSH-Px）活性、MDA和TG含量均有显著变化，胆固醇（TC）含量差异不显著。连续饲喂平欧榛子油可以提高高血脂大鼠抗氧化能力，对高血脂大鼠肾脏、心脏、骨骼肌具有一定的修复作用。

Abstract:

The hyperlipidemia model of SD rats was established and handled with gavage. The physiological indexes and histopathologic of kidneys，hearts and skeletal muscles in the model rats were observed to determine the effect of the Flat-European hybrid hazelnut oil on partial organs of rats induced by high fat diet. The results of kidney indexes test showed that the superoxide dismutase (SOD) activity was significantly increased by 2%，6%，and 15%，respectively for the high fat group treated in low，middle，and high doses using Flat-European hybrid hazelnut oil，while a significant decrease of malonaldehyde (MDA) content by 14%，28%，and 32%，and a significant increase of catalase (CAT) activity by 22%，39%，and 57%，comparing with the high fat control group. Another decrease of triglyceride (TG) content by 13%，13%，37%，and 34% was observed for soybean oil and hybrid hazelnut in low doses group，and hazelnut oil in middle and high dose group compared to the high fat control group. The results of heart indexes test showed that the differences of SOD activity and MDA content were not significant for the groups treated in low and middle doses with Flat-European hybrid hazelnut oil，however，an increase of SOD activity by12% and a decrease of MDA by 30% were significantly observed for the groups treated in high doses of Flat-European hybrid hazelnut oil. The TG contents of the groups treated with soybean oil and hybrid hazelnut in low doses significantly decreased by 8% and 7%，while those of the groups treated with hybrid hazelnut in middle and high doses extremely significantly decreased by 33% and 33%. The alanine aminotransferase (GPT) content increased by 31%，34%，33%，and 21% for soybean oil and hybrid hazelnut in low doses group，hazelnut oil in middle and high dose group compared to the high fat control group. The results of skeletal muscle test presented significant changes in SOD activity，glutathione peroxidase (GSH-Px) activity，MDA content and TG content for the high fat groups treated with Flat-European hybrid hazelnut oil. However，the change in cholesterol (TC) content was not obvious. This study revealed that the antioxidant ability of the high fat group could be improved by dosing Flat-European hybrid hazelnut oil，and the prothetic effect for kidneys，heart，and skeletal muscle was observed.