富硒大麦苗对小鼠酒精性胃溃疡的防治作用

Protective Effect of Selenium-Enriched Barley Seedling on Ethanol-Induced Gastric Ulcer in Mice

摘要:

通过建立小鼠酒精性胃溃疡模型，考察了富硒大麦苗对酒精性胃溃疡的影响。分别给小鼠灌服不同剂量的富硒大麦苗汁（0.1、0.5、1 g/mL），采用图像积分法、称质量法、记分法和分级法测量胃壁溃疡的面积与胃总面积的比值（简称溃疡面积比），并对此比值进行统计分析。数据表明，与模型组比较，富硒大麦苗组能有效预防小鼠酒精性胃溃疡的发生（P<0.05），且抗溃疡的作用与富硒浓度成正比关系。结果提示，富硒大麦苗有明显的防治小鼠酒精性胃溃疡的作用。

Abstract:

The present work aimed to investigate the influence of selenium-enriched barley seedling on ethanol-induced gastric ulcer by establishing a mice model of ethanol-induced gastric ulceration. The model mice were orally administered SEBS at different doses （0.1，0.5，1 g/mL）. The ratio of ulcer area to total stomach area （ulcer area ratio，UAR） was quantified by different methods including image integration method，gravimetric method，score method and grading method. The results were analyzed using statistic analysis. The ethanol-induced gastric ulcer in mice could be effectively prevented by SEBS （P<0.05） comparing the results of the model groups and the control groups. The protective effect was proportional to the concentration of SEBS. The results suggested that selenium-enriched barley seedling had significant ameliorative effect on ethanol-induced gastric ulcer in mice.