衍生基团对环糊精空腔疏水性的影响

Influence of Side Chains of β-cyclodextrin Derivatives on Cavity Hydrophobicity

摘要:

环糊精空腔疏水性是促进主客体复合物形成的重要驱动力之一，然而相关的研究报道非常少。作者以芘作为荧光探针，对β-环糊精及其3种不同衍生物（羟丙基-β-环糊精、甲基-β-环糊精、磺丁基醚-β-环糊精）的空腔疏水性进行比较研究。结果表明，4种环糊精的空腔疏水性强弱顺序为M-β-CD＜HP-β-CD≈S-β-CD＜β-CD，经测定包合常数大小顺序M-β-CD＜HP-β-CD＜S-β-CD＜β-CD，这与极性测定实验结果相符，进一步验证了衍生基团引入降低了环糊精空腔的疏水性。

Abstract:

Cyclodextrin cavity polarity is one of the driving forces of incorporating molecules selectively to form inclusion complexes, however, very few studies have reported. This paper aims at studying the cavity polarity of β-cyclodextrin and its three different derivatives(hydroxypropyl-β- cyclodextrin, methyl-β-cyclodextrin, sulfobutyl ether-β-cyclodextrin) by using pyrene as a fluorescent probe. The results show that the pecking order of hydrophobicity of four kinds of cyclodextrin cavity is M-β-CD