水解蛋黄粉Bonepep对骨代谢的影响

Effect of Egg Yolk Powder Hydrolysis Bonepep on the Bone Metabolism

摘要:

在小鼠和人体预实验水平上,作者旨在研究源于鸡蛋蛋黄的水解蛋黄粉(Bonepep)对骨质代谢的影响。给SD小鼠喂食10 mg/(kg·d)和100 mg/(kg·d)的Bonepep,使小鼠胫骨伸长提高了4.5%和10.3%。SD小鼠在长时间高剂量喂食后,其喂食期间各项生理生化指标与对照组比较未发生显著变化。而摄食Bonepep的小鼠尿样中脱氧吡啶啉(Dpyr)含量与未喂食的对照组降低了84.6%,其大腿端部断面中海绵骨明显减少。女性志愿者连续服用5周水解蛋黄粉后,其尿样中反映骨吸收指标的脱氧吡啶啉(DPD)与、尿中I型胶原交联N末端肽(NTx)水平无显著变化,但反映骨形成指标的骨碱性磷酸酶(BALP)活性则提高了14.6%。上述结果表明,水解蛋黄粉能够有效地抑制破骨分化和促进成骨生长。

Abstract:

In this manuscript,the effect of the egg yolk powder hydrolysis(Bonepep) on bone metabolism was investigated at rat and human level. When 10 mg/(kg·d) and 100 mg/(kg·d)Bonepep was fed to SD mice led the mice tibia elongation increased by 4.5% and 10.3%,respectively. And the physiological and biochemical indexes of mice were constant when mice were explored to high doses of Bonepep for long time. It was found that Dpyr level in urine was decreased 84.6%,and the thigh bone was significantly reduced when mice was fed Bonepep. For the female volunteers,the level of DPD and NTx,reflect the characters of bone resorption,were not significantly changed,after 5 weeks continuous taking Bonepep. However,the BALP activity,a index for bone formation,was increased by 14.6%. These results demonstrated that the egg yolk powder hydrolysis Bonepep could effectively inhibit osteoclast differentiation but promote bone growth.