吉祥草药材抗炎、止咳作用及谱效关系

Experimental Studies on Anti-Inflammatory and Antitussive Activity of Extract from Reineckia carnea and Associated Pharmacodynamics

摘要:

研究了吉祥草药材不同提取部位抗炎、止咳活性。分别采用二甲苯致小鼠耳廓肿胀法、小鼠氨水引咳法,观察吉祥草药材不同提取部位抗炎、止咳作用。结果表明,吉祥草药材食用酒精提取物3个剂量给药组都有非常显著的抗炎作用(P<0.05),高、低剂量组明显延长咳嗽时间(P<0.05),高剂量组明显减少咳嗽次数(P<0.05);水提物3个剂量组同样具有明显抗炎作用(P<0.05),水提高剂量组能明显增多咳嗽次数(P<0.05),减少咳嗽时间(P<0.05);石油醚提取物各剂量组均没有显著抗炎及止咳作用。可见,吉祥草药材食用酒精提取物及水提物具有较好的抗炎、止咳活性。

Abstract:

The objective of this study is to study relieving a cough and anti-inflammation effects of different extract part from Reineckia carnea.For this,the different extract part of Reineckia carnea were orally administrated to coughing mice induced by ammonia liquor in mice and xylene-induced mouse ear swelling model in mice,respectively,to investigate their medication effect on coughing and anti-inflammation.It was found that both ethanol extract and water extract had obvious effect on anti-inflammation(P<0.05),ethanol extract lengthened the latent period of cough at high and low dose(P<0.05),and high dose decrease cough frequency(P<0.05).The water extract fraction lengthened the latent period of cough as well as the ethanol extract at high dose.The petroleum ether extract had not obvious effect on anti-inflammation and coughing.Based on the aboved results,it can concluded that the anti-inflammatory,cough active chemical composition were mainly concentrated in the consumption of alcohol extract parts and water extract high doses parts.