羧肽酶研究进展

Research Progresses on the Carboxypeptidase

摘要:

羧肽酶(Carboxypeptidase)是一类可水解肽链C末端氨基酸残基的蛋白酶,广泛存在于高等植物、动物组织及真菌中,主要分为丝氨酸羧肽酶(EC3.4.16.-)、金属羧肽酶(EC3.4.17.-)和半胱氨酸羧肽酶(EC3.4.18.-)3个亚类。作者综述了羧肽酶的研究进展,主要包括羧肽酶的应用、性质、来源分布、克隆表达及研究意义,并对其研究前景进行了展望。

Abstract:

Carboxypeptidase is a kind of protease that cleaves the peptide bond of an amino acid residue at the carboxy-terminal end.It is widely distributed in higher plants,animals,and fungi and be divided into three sub-classes: serine-type Carboxypeptidase(EC3.4.16.-),Metal-Carboxypeptidase(EC3.4.17.-),cysteine-type carboxypeptidase(EC3.4.18.-).This review summarized the progresses of carboxypeptidase application,distribution,characteristics,cloning and expression.Furthermore,the prospect of carboxypeptidase was also suggested.