葛根和葛花对急性酒精中毒小鼠的解酒作用

Sober-Up Effect of Radix Puerariae and Flos Pueraria for Treating Acute Alcohol Poisoning Mice

摘要:

比较葛根和葛花的解酒效果及葛根素剂量与解酒效果的相关性。先给小鼠灌胃葛根和葛花提取物,30 min后灌胃白酒(5.75g/kg·bw),观察醉酒小鼠的醒酒时间及ADH法测定小鼠血液乙醇含量变化,以探讨葛根和葛花对醉酒小鼠的影响。结果低、中剂量(2.5,7.5 g/kg·bw)的葛根水提物(PRW)和葛根醇提物(PRE)能显著缩短醉酒小鼠的醒酒时间(PRW:43.3%、48.7%;PRE:51.1%、53.6%),中剂量(7.5g/kg·bw)的葛花醇提物(PFE)能有效缩短小鼠睡眠时间(24.3%);中、高剂量(7.5,10 g/kg·bw)的PRW和PRE能有效抑制酒精的吸收,降低小鼠血液乙醇浓度,而高剂量的PFW和PFE对血乙醇浓度影响较小,与对照组相比仅在240min处有显著差异。结论葛根的解酒预防效果比葛花好,PRE优于PRW,且PR中的葛根素剂量与解酒效果呈现良好的正相关性。

Abstract:

The target of this study is to compare the sober-up effect of Radix Puerariae and Flos Pueraria and the relationship of puerarin content and sober-up effect.For this,the sleeping time and the blood alcohol concentration of mice,that feed with the extract of Radix Puerariae or Flos Pueraria and feed and 5.75g/kg·bw alcohol after 30 min,were determined..It was found that t the sleeping time was decreaed by 43.3%(2.5 g/kg·bw) and 48.7%(7.5g/kg·bw) by PRW,and 51.1%(2.5 g/kg·bw).53.6%(7.5g/kg·bw) by PREThe mendium and high dose of PRW or PRE could inhibit absorption of alcohol and reduce the concentration of alcohol,and the high dose of PFWand PFE had a slightly effect on the alcohol concentration, only appearing Significant difference at 240 min.From the above results,it was concluded that the sober-up effect of Radix Puerariae is better than that of Flos Puerariaands a good positive correlation between the dose of puerarin in the PR and sober-up effect.