谷氨酸棒杆菌生产缬氨酸的代谢工程研究进展

Metabolic Engineering in Corynebacterium glutamicum to Increase L-Valine Production

摘要:

L-缬氨酸是人体必需的三种支链氨基酸之一,在生命代谢过程中起着非常重要的作用,因此被广泛应用于食品、医药及饲料等行业。目前,L-缬氨酸主要采用微生物发酵法生产,而谷氨酸棒杆菌是最常用的生产菌种。作者分析了谷氨酸棒杆菌中L-缬氨酸的生物合成途径和代谢调控,综述了对其进行代谢工程改造来提高L-缬氨酸产量的最新研究进展。

Abstract:

L-valine,one of the three branched-chain amino acids,is essential for human,and plays an important role in the metabolism of life,therefore,it is widely used in products of food,medicine and feed.L-valine is mainly produced by bacterial fermentation,and the most used bacterium is Corynebacterium glutamicum.In this article,the pathway and regulation of L-valine biosynthesis in C.glutamicum are analyzed and researches on metabolic engineering to increase L-valine production in C.glutamicum are reviewed.